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Differential effects of two lots of Aroclor 1254 on enzyme induction, thyroid hormones, and oxidative stress. (Articles).

From: Environmental Health Perspectives  |  Date: 11/1/2001  |  Author: Birnbaum, Linda S.; Burgin, Deborah E.; Derr-Yellin, Ethel C.; Diliberto, Janet J.; Kannan, Narayanan; Kodavanti, Prasada R.S.

Aroclor 1254 is a commercial mixture of polychlorinated biphenyls (PCBs), which is defined as being 54% chlorine by weight. However, the congener composition varies from lot to lot. Two lots which have been used in toxicity studies, 124-191 and 6024 (AccuStandard), were analyzed for their congener composition. Lot 6024 has approximately 10 times the dioxin toxic equivalents (TEQ) of lot 124-191. The purpose of this study was to determine if the difference in the TEQ of the two lots ...

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