CDK Inhibitor Effective For Cardiac Hypertrophy In Vitro And In Vivo.

Gene Therapy Weekly | September 20, 2001 | Copyright

2001 SEP 20 - (NewsRx.com & NewsRx.net) --

by N.R. Saltmarsh, staff medical writer - Delivery of the cyclin-dependent kinase (cdk) inhibitor p16(INK4a) by adenovirus vector has potential for treatment of cardiac hypertrophy, one of the serious complications of cardiovascular disease.

Current drug therapy is only partially successful at reducing cardiac hypertrophy, noted T. Nozato and colleagues working in Japan. They studied p16(INK4a) in vitro and in the rat model to see if it offered a better alternative.

"Adenovirus-mediated overexpression of ...

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