1,1,1-Trichloro-2,2-bis (p-Chlorophenyl)-Ethane (DDT) and Reduced Bone Mineral Density.

From: Archives of Environmental Health | Date: May 1, 2000| Author: BEARD, JOHN; MARSHALL, SONYA; JONG, KATHY; NEWTON, ROBERT; TRIPLETT-McBRIDE, TRAVIS; HUMPHRIES, BRENDAN; BRONKS, ROGER | Copyright information

The organochlorine pesticide 1,1,1-trichloro-2,2-bis (p-chlorophenyl)-ethane (DDT), is a well-known and widely dispersed "environmental estrogen" (World Health Organization Criteria no. 9; Geneva, Switzerland [1979]). Kelce et al. (Nature, 1995; 375:581-85) recently identified the DDT metabolite, 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE), has also recently been identified as a potent androgen receptor antagonist. The authors examined the relationship between serum levels of DDE and...

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