LDL Cholesterol Levels: Is Lower Always Better?

From: American Family Physician | Date: May 1, 2001| Author: | Copyright information

Reductions in low-density lipoprotein (LDL) cholesterol levels attained by therapy with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) have provided primary and secondary prevention of coronary events. The justification for targeting LDL cholesterol to its lowest possible level, however, is less clearly evidence-based. There is significant epidemiologic evidence indicating that the relationship between levels of total or LDL cholesterol and risk for coronary artery disease is curvilinear, or log-linear. Thus, in most persons with normal or mildly elevated ...

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