C282Y Mutation and Hepatic Iron Status in Hepatitis C and Cryptogenic Cirrhosis. From: Archives of Pathology & Laboratory Medicine | Date: November 1, 2000| Author: Lal, Priti; Fernandes, Helen; Koneru, Baburao; Albanese, Ernest; Hameed, Meera | COPYRIGHT 2000 College of American Pathologists. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group.Copyright information

* Background.--Increased iron deposition in liver is seen in both primary and secondary hemochromatosis. However, it is not uncommon to see significant iron deposition in a liver biopsy, explant, or autopsy specimen without any significant clinical risk factor. Because of the discovery of the candidate gene (HFE) for hereditary hemochromatosis, we may now be able to screen high-risk patient populations for the abnormal mutation (C282Y).

Materials and Methods.--In this study we anal...

Related newspaper, magazine, and journal articles from HighBeam Research

	Evidence for non-HFE linked hemochromatosis in Asian Indians Indian Journal of Medical Sciences ; Histone Family E (HFE) gene mutations are important in causation of primary hemochromatosis in Caucasians[1] (HFE, OMIM 235200). Mutation H63D (C G transversion) increases relative risk of developing hemochromatosis in individuals heterozygous for C282Y mutation. Mutations in the HFE protein alter
	Hemochromatosis Gene Sequence Deviations in German Patients with Porphyria Cutanea Tarda Physiological Research ; Summary Patients with porphyria cutanea tarda (PCT) reveal a susceptibility to reversible inactivation of hepatic uroporphyrinogen decarboxylase, which might be triggered by alcohol, hepatitis C virus infection, and iron overload. Inherited factors that may predispose to clinically overt PCT also
	HFE genotyping using multiplex allele-specific polymerase chain reaction and capillary electrophoresis Archives of Pathology & Laboratory Medicine ; Context.-Hereditary hemochromatosis is recognized as one of the most common autosomal recessive disorders, with a prevalence of 1 in 200 to 400 in the white population. Early detection and treatment are completely effective in preventing pathology. It is anticipated that testing for hereditary
	Hereditary Hemochromatosis.(patient education sheet) American Family Physician ; What is hereditary hemochromatosis? What causes it? Hereditary hemochromatosis is a health problem that is passed from parents to children. It is inherited by passing on the HFE gene. The HFE gene makes your body store too much iron. The extra iron builds up in your body. This is called iron
	Noncitrus Fruits as Novel Dietary Environmental Modifiers of Iron Stores in People With or Without HFE Gene Mutations Mayo Clinic Proceedings ; OBJECTIVE: To investigate whether citrus fruit, noncitrus fruit, and other dietary factors act as environmental modifiers of iron status in the absence or presence of hemochromatotic HFE gene mutations. PARTICIPANTS AND METHODS: Iron studies, HFE genotypic analyses, and dietary data from a survey

See all results.