Microcystic Cyanobacteria Extract Induces Cytoskeletal Disruption and Intracellular Glutathione Alteration in Hepatocytes.

From: Environmental Health Perspectives | Date: July 1, 2000| Author: Ding, Wen-Xing; Shen, Han-Ming; Ong, Choon-Nam | Copyright information

Microcystins are a group of highly liver-specific toxins, although their exact mechanisms of action remain unclear. We examined the effects of microcystic cyanobacteria extract (MCE) collected from a contaminated water source on the organization of cellular microtubules (MTs) and microfilaments (MFs) in hepatocytes. We also investigated the effects on lactate dehydrogenase (LDH) leakage and intracellular glutathione (GSH). Primary cultured rat hepatocytes exposed to MCE (equivalent ...

Read all of this article with a FREE trial to HighBeam Research

Related newspaper, magazine, and journal articles from HighBeam Research

Microcystic Cyanobacteria Extract Induces Cytoskeletal Disruption and Intracellular Glutathione Alteration in Hepatocytes.
Environmental Health Perspectives ; Microcystins are a group of highly liver-specific toxins, although their exact mechanisms of action remain unclear. We examined the effects of microcystic cyanobacteria extract (MCE) collected from a contaminated water source on the organization of cellular microtubules (MTs) and microfilaments
Alteration of intracellular cysteine and glutathione levels in alveolar macrophages and lymphocytes by diesel exhaust particle exposure. (Articles).
Environmental Health Perspectives ; The purpose of this study was to characterize the effects of diesel exhaust particles (DEP) on thiol regulation in alveolar macrophages (AM) and lymphocytes. We obtained AM and lymph node (thymic and tracheal) cells (LNC) (at different time points) from rats exposed intratracheally to DEP (5 mg/kg)
Methionine and cysteine affect glutathione level, glutathione-related enzyme activities and the expression of glutathione S-transferase isozymes in rat hepatocytes
The Journal of Nutrition ; Shih-Tsung Wang,* Haw-Wen Chen,* Lee-Yan Sheen^ and Chong-Kuei Lii*4 ABSTRACT Methionine and cysteine are constituents of glutathione. To understand the effects of these two sulfur amino acids on the glutathione (GSH)-dependent detoxification defense system, intracellular GSH and GSH-related enzyme
Nutrients and HIV. (Letters to the Editor).
Townsend Letter for Doctors and Patients ; Editor: I read with interest the past issue dedicated to Nutrients and HIV (April 2002, #225). I wrote an article on the topic of nutrients for HIV and examined some of the controversies surrounding this virus, which was published in the Townsend Letter (Dec. 1996, #161, page 50) and entitled
Diallyl Trisulfide Modulates Cell Viability and the Antioxidation and Detoxification Systems of Rat Primary Hepatocytes1
The Journal of Nutrition ; ABSTRACT This study investigated the effects of various concentrations of diallyl trisulfide (DATS) and incubation times on cell viability, glutathione (GSH) content, and GSH-related enzyme activity in rat primary hepatocytes. Isolated and cultured primary rat hepatocytes were used as an