Insulin Glargine Injection (Lantus--Aventis Pharmaceuticals Inc.).

Internal Medicine Alert | July 15, 2000| | Copyright

INSULIN GLARGINE IS A NEW LONG-ACTING INSULIN produced by recombinant DNA technology. The drug is an analog of human insulin with asparagine replaced by glycine in position A21 and two arginines are added to the C-terminus of the B-chain. [1] These changes result in a relatively constant concentration/time profile over 24 hours allowing just one shot a day. The drug is produced using a nonpathogenic strain of Escherichia coli and is manufactured by Hoechst Marion Roussel in Germany. It will be marketed in this country by Aventis under the trade name Lantus.

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