Inhaled Crocidolite Mutagenicity in Lung DNA.

From: Environmental Health Perspectives | Date: April 1, 2000| Author: Binet, Stephane; Bottin, Marie-Claire; Coulais, Catherine; Kauffer, Edmond; Keith, Gerard; Martin, Patrick; Monhoven, Nathalie; Rihn, Bertrand; Steiblen, Guy; Yvon, Francois Vigneron, Jean Claude | Copyright information

We used transgenic mice carrying the lacI reporter gene to study the mutagenesis potential of asbestos crocidolite. The animals were exposed by nose-only inhalation to an aerosol containing 5.75 mg/[m.sup.3] crocidolite dust for 6 hr/day and 5 consecutive days. After 1, 4, and 12 weeks, we examined four end points: the cytology of bronchoalveolar lavage, the lung load of crocidolite, the hydrophobic DNA adducts, and the mutations in the lacI reporter gene. Twelve weeks after exposu...

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