Effects of Alcohol on Baseline Startle and Prepulse Inhibition in Young Men at Risk for Alcoholism and/or Anxiety Disorders(*).

From: Journal of Studies on Alcohol | Date: January 1, 2000| Author: AMELI, REZVAN; GRILLON, CHRISTIAN; O'MALLEY, STEPHANIE S.; SINHA, RAJITA | Copyright information

Objective: This study examined the hypothesis that a decreased reaction to alcohol and a deficit in prepulse inhibition (PPI) of the startle reflex are characteristics of male offspring of alcoholics without comorbid anxiety disorder. Method: Male offspring (N = 51) with a parental history of (1) alcoholism only, (2) anxiety disorder only, (3) alcoholism and anxiety disorder, and (4) no psychiatric disorder participated in an experiment examining the effects of alcohol on the acoustic start...

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