Report summarizes apoptosis study findings from Georgia State University.

Cancer Weekly | November 10, 2009 | Copyright

"Caspase-mediated apoptosis has important roles in normal cell differentiation and aging and in many diseases including cancer, neuromuscular disorders and neurodegenerative diseases. Therefore, modulation of caspase activity and conformational states is of therapeutic importance," scientists writing in the journal Apoptosis report (see also Apoptosis).

"We report crystal structures of a new unliganded conformation of caspase-7 and the inhibited caspase-7 with the tetrapeptide Ac-YVAD-Cho. Different conformational states and mechanisms for substrate recognition have ...

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