Investigators at Columbia University zero in on acromegaly.(Report)

Biotech Week | September 23, 2009 | Copyright

"GH and IGF-I are nitrogen retaining and anabolic, but the impact of long-term exposure to supraphysiological GH and IGF-I, either from endogenous overproduction in acromegaly or exogenous sources, on skeletal muscle (SM) mass is not clear. The objectives of the study were to assess SM mass by whole-body magnetic resonance imaging (MRI) in acromegaly and test the hypothesis that dual-energy x-ray absorptiometry (DXA) lean tissue mass-derived estimates of SM accurately estimate true SM mass," scientists writing in the Journal of Clinical Endocrinology & Metabolism report (see ...

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