Research results from L.R. Montes and co-authors update knowledge of hemolysis.

Proteomics Weekly | December 29, 2008 | Copyright

"Hot-cold hemolysis is the phenomenon whereby red blood cells, preincubated at 37 degrees C in the presence of certain agents, undergo rapid hemolysis when transferred to 4 degrees C. The mechanism of this phenomenon is not understood. PlcHR(2), a phospholipase C/sphingomyelinase from Pseudomonas aeruginosa, that is the prototype of a new phosphatase superfamily, induces hot-cold hemolysis," researchers in Bilbao, Spain report (see also Hemolysis).

"We found that the sphingomyelinase, but not the phospholipase C activity, is essential for hot-cold hemolysis because ...

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