Recent advances in the genetics of susceptibility to and treatment of breast cancer.(Feature Article)(Report)

Advances in Breast Cancer | June 1, 2008| | Copyright

Introduction

Since the middle of the 1990s, with the seminal identification of mutations in the breast cancer genes BRCA1 and BRCA2, which cause early onset familial breast cancer, limited progress has been made in defining additional genetic risk factors for breast cancer until very recently. A third major genetic locus, the putative BRCA3, has not been defined to account for other familial breast cancer cases. However, rather than concentrating on traditional linkage studies in multiple affected family members, recent approaches have successfully focused on ...

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