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Biotech seeking to disrupt how bacteria communicate.(Pico Pharmaceuticals)
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Pico Pharmaceuticals, a biotech startup with plans to make more potent cancer and anti-infective drugs, is starting off small. A staff of three full-time employees. A modest office in the University Towne Center area.
But it isn't without grand plans.
Pico aims to tackle common problems that have plagued the field of anti-infective drugs for decades, namely the loss of a drug's effectiveness over time. It has also set its sights on developing an oral cancer drug without some of the adverse side effects seen in standard treatments.
CEO Tim Boyd, ...
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Electrocatalytic Oxidation of Guanine, Guanosine, and Guanosine Monophosphate
Magazine article from: Biophysical Journal
; ...ABSTRACT The electrochemical behavior of guanine, guanosine, and guanosine monophosphate...hydrogen electrode were determined for guanine and guanosine/GMP under physiological...The first to oxidize the base of DNA is guanine, oxidized either directly or through...
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RADICALS DERIVED FROM GUANINE: STRUCTURES AND ENERGETICS
Magazine article from: Collection of Czechoslovak Chemical Communications
; ...affinities (EA) of five radicals derived from guanine by removing a hydrogen atom are predicted...density functional methods. The most stable guanine radical arises from the removal of the...EA^sub ad^) for the five possible guanine radicals are substantial, in the range...
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Formation pathways of a guanine-quadruplex DNA revealed by molecular dynamics and thermodynamic analysis of the substates
Magazine article from: Biophysical Journal
; ...guanine quadruplex structure. Guanine quadruplexes are stabilized...layers of Hoogsteen paired guanine residues (Fig. 1 A), and...sequences containing stretches of guanines under physiological conditions...resolution data exist now for many guanine quadruplex structures adopted...
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New dihydro OO'bis(salicylidene) 2,2' aminobenzothiazolyl borate complexes: kinetic and voltammetric studies of dimethyltin copper complex with guanine, adenine, and calf thymus DNA.
Magazine article from: Bioinorganic Chemistry and Applications
; ...The interaction of complex (5) with guanine, adenine, and calf thymus DNA was studied...hyperchromic effect" in the presence of guanine and calf thymus DNA. Indicative of strong...binds through [N.sub.7] position of guanine base, while the adenine shows binding...
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Separation of guanine and hypoxanthine with some ionic liquids in RP-HPLC.(reversed phase high performance liquid chromatography)
Magazine article from: American Journal of Applied Sciences
; Abstract: In this paper, guanine and hypoxanthine were separated with...methylsulfate ([OMIm][MS]) were used. Guanine and hypoxanthine couldn't be separated...the ionic liquid for separation of guanine and hypoxanthine as an eluent modifier...
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Molecular Dynamics Simulations of Guanine Quadruplex Loops: Advances and Force Field Limitations
Magazine article from: Biophysical Journal
; ...architecture. INTRODUCTION Guanine quadruplex (G-DNA) molecules...sequences are particularly guanine-rich and readily form quadruplexes...cyclically hydrogen-bonded guanines. Several consecutive quartets...channel interacting with the guanine carbonyl groups between the...
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A REGIOSELECTIVE SYNTHESIS OF ALKYL 2-(GUANIN-9-YL)ACETATES AS PNA BUILDING BLOCKS FROM 7-(4-NITROBENZYL)GUANINE DERIVATIVES
Magazine article from: Collection of Czechoslovak Chemical Communications
; Guanine derivatives substituted at N^sup 7^ with 4...the regioselective N^sup 9^-alkylation of guanine. Given the capricious removal of (substituted) benzyl groups from guanine derivatives and pent-4-enoylation of guaninium...
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Guanosine assays can estimate the plasma biomarker guanine deaminase.
Newspaper article from: Biotech Week
; ...assays can estimate the plasma biomarker guanine deaminase. According to a study from Wales, "plasma guanine deaminase (guanase; GD) is well established...plasma GD activity is routine since both guanine and 8-azaguanine, the substrates of...
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Guanine nucleotide exchange protein involved in dendritic formation.
Newspaper article from: Drug Week
; ...localization of the mRNA for EFA6A, a guanine nucleotide exchange protein for ARF6...in dendritic formation. "EFA6A is a guanine nucleotide exchange protein (GEP) that...localization of the mRNA for EFA6A, a guanine nucleotide exchange protein for ARF6...
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Alsin is a Rab5 and Rac1 guanine nucleotide exchange factor.
Newspaper article from: Obesity, Fitness & Wellness Week
; ...large protein, alsin, is a Rab5 and Rac1 guanine nucleotide exchange factor, and may play...that the Vps9p domain of alsin has Rab5 guanine nucleotide exchange activity. In addition...interacted specifically with and acted as a guanine nucleotide exchange factor for Rac1...
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