Research reports on drug resistance from Wayne State University, Medical Department provide new insights.

Biotech Week | May 13, 2009 | Copyright

According to recent research from the United States, "Overexpression of efflux pump genes conferring multidrug resistance (MDR) in Staphylococcus aureus results in reduced susceptibility to select biocides, dyes and fluoroquinolones. Reserpine is commonly used as an inhibitor of MDR efflux pumps and previous work from our laboratory using a reserpine-based screen to identify clinical isolates with an efflux phenotype revealed that nearly one-half overexpressed norA-B-C, mepA or mdeA."

"The accuracy of reserpine in predicting efflux pump gene overexpression in ...

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