ER stress affects processing of MHC class I-associated peptides.(Research article)(endoplasmic reticulum)(Major histocompatibility complex)(Report)

BMC Immunology | February 16, 2009| | Copyright

Authors: Diana P Granados [1]; Pierre-Luc Tanguay [2]; Marie-Pierre Hardy [1]; Étienne Caron [1]; Danielle de Verteuil [1]; Sylvain Meloche [2]; Claude Perreault (corresponding author) [1]

Background

The ultimate role of the immune system in host defense is to eliminate infected and transformed cells [1, 2]. A fundamental feature of infected and neoplastic cells is that they are stressed cells [3, 4, 5]. In line with this, the innate immune system uses receptors such as NKG2D to recognize stressed cells [4, 6, 7]. One key question, however, is ...

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