Research from University of Erlangen has provided new data on arteriosclerosis.(Report)

Biotech Week | February 18, 2009 | Copyright

"Blockade of the CD40-CD154 costimulatory pathway can prolong allograft survival, but does not prevent the development of transplant arteriosclerosis in several models. In this study, we investigated the mechanisms of CD40-CD154-independent transplant arteriosclerosis in major histocompatibility complex (MHC)-class I-mismatched aortic allografts," researchers in Erlangen, Germany report (see also Arteriosclerosis).

"MHC class I-mismatched CBK (H2(k) + K-b) donor aortas were transplanted into CBA (H2(k)) recipients who can only recognize the graft through CD8(+) T ...

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