Peptide length significantly influences in vitro affinity for MHC class II molecules.(Research)(major histocompatibility complex)(Report)

Immunome Research | November 26, 2008| | Copyright

Authors: Cathal O'Brien [1]; Darren R Flower [2]; Conleth Feighery (corresponding author) [1]

Background

Classical major histocompatibility complex (MHC) molecules are divided into two groups: class I and class II [1]. Each contains large numbers of alleles, all of which bind antigen for cell surface presentation to T cells. MHC class I molecules comprise a single polymorphic chain coupled to a single conserved protein: [beta]2 microglobulin. In contrast, MHC class II molecules comprise two polymorphic subunits: an [alpha] and a [beta] chain. A ...

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