Scientists at University of Siena discuss research in enzyme research. Biotech Week | January 14, 2009 | COPYRIGHT 2009 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information) Copyright

"Nitric oxide (NO) is a gaseous mediator that exerts key regulatory functions in mammalian cells. Low levels of NO exert homeostatic functions and counteract inflammation, whereas high amounts of NO cause tissue destruction and cellular death," investigators in Siena, Italy report (see also Enzyme Research).

"Herein we describe a new class of nitric oxide synthase (NOS) inhibitor NO-donoting drugs (NI-NODs). Human endothelial cells and human monocyte-based activity screening showed that NI-NODs inhibit IL-1 beta production, modulate PGE(2) production, and protect ...

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