Sex dependent imprinting effects on complex traits in mice.(Research article)(Report)

While most genes are expressed from both the paternally and maternally derived allele, imprinted loci show parent-of-origin-dependent gene expression such that either the paternal or the maternal allele only is expressed [1, 2]. This monoallelic pattern of gene expression is usually caused by differential methylation of the paternal and maternal allele [3] and results in phenotypic differences between the two heterozygotes (where the ...

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