Modification of carbonic anhydrase II with acetaldehyde, the first metabolite of ethanol, leads to decreased enzyme activity.(Research article)(Report)

BMC Biochemistry | November 27, 2008| | Copyright

Authors: Fatemeh Bootorabi [1,2]; Janne J änis [3]; Jarkko Valjakka [1]; Sari Isoniemi [3]; Pirjo Vainiotalo [3]; Daniela Vullo [4]; Claudiu T Supuran [4]; Abdul Waheed [5]; William S Sly [5]; Onni Niemelä [6]; Seppo Parkkila (corresponding author) [1,2]

Background

Acetaldehyde, a product of ethanol metabolism, has been suggested to play a pivotal role in the toxicity of ethanol to human tissues [1, 2, 3]. It can form covalent, stable or unstable adducts with amino acids and nucleophilic biomolecules [4, 5, 6, 7, 8, 9, 10]. ...

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