Research from Kumamoto University reveals new findings on cancer.

Cancer Weekly | December 9, 2008 | Copyright

"Non-steroidal anti-inflammatory drugs (NSAIDs) show chemopreventive effects; however, the precise molecular mechanism of these effects is still unclear. On the other hand, the expression of proteins that form tight junctions (TJs) (such as claudins) in clinically isolated tumors is frequently altered relative to normal tissue," scientists in Kumamoto, Japan report (see also Cancer).

"We previously reported that NSAIDs upregulate the expression of claudin-4 and that this upregulation contributes to NSAID-dependent inhibition of both migration activity and ...

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