Clinical update; impact of HIV protease inhibitors on the treatment of HIV-infected tuberculosis patients with rifampin.(Notice To Readers)

Morbidity and Mortality Weekly Report | October 25, 1996 | Copyright

In 1995 and 1996, the Food and Drug Administration (FDA) approved three products in the new protease inhibitor class of drugs-saquinavir (Invirase[TM]), ritonavir (Norvir[TM]), and indinavir (Crixivan[TM]). Another drug in this class of agents, nelfinavir (Viracept[TM]) (Agouron Pharmaceuticals), is expected to be available soon from the manufacturer through an expanded-access program. All four drugs, which inhibit HIV protease and thus interfere with viral maturation and replication, are the most potent antiretroviral agents available to treat patients with HIV disease (1). ...

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