Toxicol Sci: MRP2 and the DMPS- and DMSA-mediated elimination of mercury in TR- and control rats exposed to thiol s-conjugates of inorganic mercury.(multidrug resistance protein, 3-dimercaptopropane-1-sulfonic acid, 3-dimercaptosuccinic acid)(Author abstract)(Clinical report) Alternative Medicine Review | September 1, 2008| | COPYRIGHT 2008 Thorne Research Inc. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information) Copyright

Cysteine (Cys) and homocysteine (Hcy)-S-conjugates of inorganic mercury (Hg(2+)) are transportable species of Hg(2+) that are taken up readily by proximal tubular cells. The metal chelators, 2, 3-dimercaptopropane-1-sulfonic acid (DMPS) and meso-2, 3-dimercaptosuccinic acid (DMSA), have been used successfully to extract Hg(2+) from these cells, presumably via the multidrug resistance protein, Mrp2. In the current study, we tested the hypothesis that Mrp2 is involved in the DMPS- and DMSA-mediated extraction of Hg(2+) following administration of Hg(2+) as an S-conjugate of Cys ...

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