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Mutant gene is not always a killer. (the number of CAG repeats contained in gene linked to Huntington's disease is not enough to cause the neurological disorder)(Biomedicine)(Brief Article)
From:
Science News
| Date:
August 3, 1996
| COPYRIGHT 1996 Science Service, Inc. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group.Copyright information
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The gene behind the neurological disorder Huntington's disease continues to surprise investigators. After finding the gene in 1993, researchers discovered that the deadly disease results only when the gene contains an abnormally large number of occurrences of a small sequence of DNA. If a person has too many of these so-called CAG repeats, Huntington's usually strikes. The more repeats the person's gene has, the earlier the disease tends to start. While Huntington's usually strikes adults, the disease has shown up in teenagers.
Recently, investigators have tried to pin down ...
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; ...of mutation that causes Huntington's disease and several similar...stem from an excess of CAG repeats. Huntington's disease, for example...harbors about 40 or more CAG repeats (SN: 6/10/95, p. 360). Excess CAG repeats in a given gene add extra...neurodegenerative ...
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Single-Step Scalable-Throughput Molecular Screening for Huntington Disease
; BACKGROUND: Huntington disease (HD) is a fatal...Association for Clinical Chemistry Huntington disease (HD)6 (OMIM 143100...Alleles with ≤26 CAG repeats are stable and considered...alleles. Alleles with 36-39 CAG repeats are meiotically unstable...full penetrance (≥40 ...
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Huntington's disease in all (three) siblings and their one parent
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; TO find the difference between Huntington and Charleston, you need only look at...display at midnight and street dancing. In Huntington, there were neighborhood celebrations...sponsored a teen celebration at the Huntington Civic Arena. Bowlers celebrated at bowling...
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