Findings from University of Magdeburg in neurochemistry reported.

Chemicals & Chemistry | August 29, 2008 | Copyright

"The protein p42(IP4) (aka Centaurin alpha-1) is highly enriched in the brain and has specific binding sites for the membrane lipid phosphatidylinositol 3,4,5-trisphosphate and the soluble messenger inositol 1,3,4,5-tetrakisphosphate (Ins(1,3,4,5)P-4; IP4). p42(IP4) shuttles between plasma membrane, cytosol and cell nucleus. However, the molecular function of p42(IP4) is still largely unclear," investigators in Magdeburg, Germany report.

"Here, we report a novel interaction partner for p42(IP4), Ran binding protein in microtubule-organizing center (RanBPM). RanBPM is ...

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