Norepinephrine to increase blood pressure in endotoxaemic pigs is associated with improved hepatic mitochondrial respiration.(Research)(Clinical report)

Critical Care | July 14, 2008| | Copyright

Authors: Tomas Regueira [1]; Bertram B änziger [2]; Siamak Djafarzadeh [1]; Sebastian Brandt [2]; Jose Gorrasi [1]; Jukka Takala [1]; Philipp M Lepper [1]; Stephan M Jakob (corresponding author) [1]

Introduction

Septic shock is associated with high mortality, especially when antibiotic treatment and fluid resuscitation are delayed and oxygen delivery remains insufficient [1]. Despite recent recommendations on blood pressure targets in septic shock [2, 3], the goals in clinical trials vary substantially [4]. Recently, Varpula and coworkers ...

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