Epigenetic modification of histone 3 at lysine 9 in sheep zygotes and its relationship with DNA methylation.(Research article)

BMC Developmental Biology | May 29, 2008| | Copyright

Authors: Jian Hou (corresponding author) [1]; Lei Liu [1]; Jing Zhang [1]; Xiu-Hong Cui [1]; Feng-Xiang Yan [1]; Hong Guan [1]; Yong-Fu Chen [1]; Xiao-Rong An (corresponding author) [1]

Background

During mammalian fertilization, two sets of genomes from male and female gametes join together and then undergo large-scale reprogramming to restore the totipotency. However, although reside in the same zygotic cytoplasm, the paternal and maternal genomes are reprogrammed in different ways. It is well known that several epigenetic modifications are involved in ...

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