Development and evaluation of a chloramphenicol hypertonic ophthalmic solution.(Research Paper)(Report)

Indian Journal of Pharmaceutical Sciences | January 1, 2008| | Copyright

Byline: A. Jithan, C. Mohan, M. Vimaladevi

Hypertonic ophthalmic solutions are used to treat ocular diseases associated with edema. In this study, we developed a chloramphenicol hypertonic ophthalmic solution. These drops were developed based on the cosolvency and additional dielectric constant concepts. Two different solvents: PEG 300 and glycerol were used as cosolvents. Solubility curves were plotted. Based on the solubility curves, two different solutions were selected. These solutions were evaluated for physical parameters and accelerated stability. The results ...

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