Evolution of hedgehog and hedgehog -related genes, their origin from Hog proteins in ancestral eukaryotes and discovery of a novel Hint motif.(Research article)

BMC Genomics | March 11, 2008| | Copyright

Authors: Thomas R B Ã¼rglin (corresponding author) [1]

Background

The Hedgehog (Hh) signaling pathway has been shown to be of fundamental importance for patterning and cell proliferation in animal development (for review see [1, 2, 3, 4]). Mutations in this pathway cause congenital defects and several types of cancer such as basal cell carcinoma and medulloblastoma [5, 6, 7, 8]. A key molecule of the pathway is Hh, a secreted ligand that can act as morphogen. Drosophila melanogaster

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