Chiral phenyl-bis(oxazoline) as an efficient auxiliary for asymmetric catalysis *.(Report)

From: Pure and Applied Chemistry | Date: April 1, 2008| Author: | Copyright information

Abstract: A new class of phenyl-bis(oxazoline) auxiliaries was readily prepared from isophthaloyl chloride and appropriate [beta]-amino alcohols, and the derived rhodium complexes underwent new cyclization reactions at the metal center and exhibited high catalytic efficiency for asymmetric conjugate reduction of [alpha],[beta]-unsaturated carbonyl compounds and reductive aldol reactions of aldehydes and ketones.

Keywords: asymmetric catalysis; rhodium; oxazoline; reduction; C-H bond activation.

INTRODUCTION

The synthesis of organic auxiliaries for transition-metal ...

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