Curcumin prevents and reverses murine cardiac hypertrophy.(Research article)

Journal of Clinical Investigation | March 1, 2008| | Copyright

Introduction

Cardiac hypertrophy is an adaptive enlargement of the myocardium in response to increased workload, characterized by an increase in the size of individual cardiac myocytes and whole-organ enlargement. Although cardiac hypertrophy may initially be compensatory, sustained pathologic hypertrophy is deleterious and may lead to heart failure, sudden death, and stroke (1-3). Histone acetylation is one of the key control points for gene regulation in the hypertrophic myocardium (4). Acetylation of histone tails, mediated by histone acetyltransferases (HATs), ...

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