Histone H3K4 demethylases are essential in development and differentiation (1).(MINIREVIEW / MINISYNTHESE)(Report)

Biochemistry and Cell Biology | August 1, 2007| | Copyright

Abstract: Lysine histone methylation is one of the most robust epigenetic marks and is essential for the regulation of multiple cellular processes. The methylation of Lys4 of histone H3 seems to be of particular significance. It is associated with active regions of the genome, and in Drosophila it is catalyzed by trithorax-group proteins that have become paradigms of developmental regulators at the level of chromatin. Like other histone methylation events, H3K4 methylation was considered irreversible until the identification of a large number of histone demethylases indicated ...

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