Large-scale trial establishes benefits of long-term management of prostate disease (PART V OF V). Business Wire | November 1, 1995 | COPYRIGHT 1995 Business Wire. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information) Copyright

WEST POINT, Pa.--(BUSINESS WIRE)--Nov. 1, 1995-- -0- Pregnancy

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PROSCAR is not indicated for use in women. Administration of finasteride to pregnant rats at doses ranging from 100 microg/kg/day to 100 mg/kg/day (1-1000 times the recommended human dose) resulted in dose-dependent development of hypospadias in 3.6 to 100% of male offspring. Pregnant rats produced male offspring with decreased prostatic and seminal vesicular weights, delayed preputial separation and transient nipple development when given finasteride at > or =30 ...

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