Adrenomedullin signaling is necessary for murine lymphatic vascular development.(Research article)

Journal of Clinical Investigation | January 1, 2008| | Copyright

Introduction

The lymphatic vascular system is an open-ended network of endothelial cell-lined vessels that works to transport extravasated tissue fluid, proteins, metabolites, and cells from the interstitial space back to the circulatory system via the thoracic duct (1). Lymphatic capillaries, which lack a basement membrane, are made of overlapping endothelial cells that adhere to the extracellular matrix through fibrillin-rich, pressure-sensing anchoring filaments. Under conditions of interstitial edema, lymphatic endothelial cells (LECs) stretch apart to collect ...

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