Homocysteine-lowering therapy: a role in stroke prevention?(Brief article)(Clinical report)

From: Alternative Medicine Review | Date: December 1, 2007| Author: | Copyright information

Homocysteine-lowering therapy: a role in stroke prevention? Spence JD. Lancet Neurol 2007;6:830-838.

On the basis of the results of several recent clinical trials, many researchers have concluded that vitamin therapy designed to lower total homocysteine concentrations is not effective in reducing the risk of cardiovascular events. However, whereas almost all myocardial infarctions are due to plaque rupture, stroke has many more pathophysiological mechanisms, and thrombosis-which is increased by raised total homocysteine concentrations-has an important role in many of these ...

Read all of this article with a FREE trial to HighBeam Research

Related newspaper, magazine, and trade journal articles from HighBeam Research

(Including press releases, facts, information, and biographies)

Vitamin therapy and children with Down Syndrome: a review of research.
; ...research designs, have demonstrated that vitamin therapy is not useful for members of this...including children with Down syndrome. By vitamin therapy we mean the administration of vitamins...functioning. Belief in the effectiveness of vitamin therapy finds its theoretical rationale ...
Vitamin therapy produces regression of atherosclerosis.
; ...plaque area) was 0.21 cm2/year before vitamin therapy, and -0.049 cm2/year after vitamin therapy (p = 0.0001). Among patients with initial...of plaque was 0.13 cm2/year before vitamin therapy and -0.024 cm2/year after vitamin therapy...
A common mutation A1298C in human methylenetetrahydrofolate reductase gene: Association with plasma total homocysteine and folate concentrations
; ...Reductase Gene: Association with Plasma Total Homocysteine and Folate Concentrations' ABSTRACT...mutation, and related them to plasma total homocysteine and folate concentrations. We studied...had significantly greater plasma total homocysteine concentrations (P < 0.01) than...
Total homocysteine and estrogen status indicators in the Third National Health and Nutrition Examination Survey.
; Total homocysteine and estrogen status indicators...that estrogen status modulates total homocysteine concentration, a risk factor for...1991-1994. The geometric mean serum total homocysteine concentration was compared among...
NEW VITAMIN THERAPY COMBINATIONS SEEN BOOSTING BUSINESS AT SKINCEUTICALS.(Brief Article)
; ...Inc., a $12 million treatment company here where topical vitamin therapy and other medical links to skin care drive the growing business...20 percent next year. Leading the way are new combination vitamin therapy products containing stabilized formulations of vitamins...
Facts and Recommendations about Total Homocysteine Determinations: An Expert Opinion
; Background: Measurement of plasma total homocysteine has become common as new methods...with increased concentrations of total homocysteine. The purpose of this review is to...opinion on the practical aspects of total homocysteine determinations in clinical practice...
The Methylenetetrahydrofolate Reductase 677C[arrow right]T Polymorphism and Dietary Folate Restriction Affect Plasma One-Carbon Metabolites and Red Blood Cell Folate Concentrations and Distribution in Women1,2
; ...negative correlations between plasma total homocysteine concentrations and total or 5-methyl...abundance was predictive of plasma total homocysteine concentration despite no significant...T genotype. In conclusion, plasma total homocysteine concentrations in subjects with the...
Selenium supplements do not increase plasma total homocysteine concentrations in men and women
; ...Supplements Do Not Increase Plasma Total Homocysteine Concentrations in Men and Women1...Studies in rats indicate that plasma total homocysteine (tHcy) is decreased in selenium deficiency...lifestyle determinants of plasma total homocysteine distribution: the Hordaland Homocysteine...
In the cystathionine (Beta)-synthase knockout mouse, elevations in total plasma homocysteine increase tissue S-adenosylhomocysteine, but responses of S-adenosylmethionine and DNA methylation are tissue specific
; ...assess the effect of elevated plasma total homocysteine caused by cystathioninebeta-synthase...sex-matched wild-type mice. Plasma total homocysteine levels, S-adenosylmethionine and S-adenosylhomocyst...vitro DNA methyl acceptance. Plasma total homocysteine concentration in ...
Homocysteine-Lowering Action Is Another Potential Cardiovascular Protective Factor of Aged Garlic Extract1-3
; ...respectively. Plasma concentrations of total homocysteine were elevated to the highest level...folate-deficient diet decreased plasma total homocysteine concentration by 30%. Hyperhomocysteinemia...supplementation. The reduction in total homocysteine of the severely ...