Efficacy of a soy moisturizer in photoaging: a double-blind, vehicle-controlled, 12-week study.(Clinical report) From: Journal of Drugs in Dermatology | Date: September 1, 2007| Author: Leyden, James J.; Nebus, Judith; Wallo, Warren | COPYRIGHT 2007 Journal of Drugs in Dermatology, Inc. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group.Copyright information

Abstract

Serine protease inhibitors (soybean trypsin inhibitor [STI] and Bowman-Birk protease inhibitor [BBI]) found in soybeans have been shown to inhibit melanosome phagocytosis by keratinocytes via protease-activated receptor 2 (PAR-2). Preclinical studies have confirmed the skin lightening potential of these molecules. In this study, we investigated the efficacy of a novel soy moisturizer containing nondenaturated STI and BBI for the improvement of skin tone, pigmen...