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Genetic polymorphisms influencing arsenic metabolism: evidence from Argentina.(Research)(Report)
From:
Environmental Health Perspectives
| Date:
April 1, 2007| Author:
| COPYRIGHT 2007 National Institute of Environmental Health Sciences. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group.Copyright information
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The susceptibility to arsenic-induced diseases differs greatly between individuals, possibly due to interindividual variations in As metabolism that affect retention and distribution of toxic metabolites. To elucidate the role of genetic factors in As metabolism, we studied how polymorphisms in six genes affected the urinary metabolite pattern in a group of indigenous women (n = 147) in northern Argentina who were exposed to approximately 200 [micro]g/L As in drinking water. These women had low urinary percentages of monomethylated As (MMA) and high percentages of dimethylated As ...
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