Proton magnetic resonance spectroscopic evidence of glial effects of cumulative lead exposure in the adult human hippocampus.(Research)(Clinical report)

From: Environmental Health Perspectives | Date: April 1, 2007| Author: Weisskopf, Marc G.; Hu, Howard; Sparrow, David; Lenkinski, Robert E.; Wright, Robert O. | Copyright information

BACKGROUND: Exposure to lead is known to have adverse effects on cognition in several different populations. Little is known about the underlying structural and functional correlates of such exposure in humans.

OBJECTIVES: We assessed the association between cumulative exposure to lead and levels of different brain metabolite ratios in vivo using magnetic resonance spectroscopy (MRS).

METHODS: We performed MRS on 15 men selected from the lowest quintile of pa...

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