Preventing colorectal adenomas.

Bandolier | November 1, 2006 | Copyright

Bandolier 129 had a quick review of trials of aspirin, coxibs, and NSAIDs to prevent polyp recurrence in familial polyposis or prevention of adenomas. In familial polyposis there was some evidence that coxibs and NSAIDs may prevent polyp recurrence, but trials tended to be small and short. Three trials of low dose aspirin to prevent colorectal adenomas were longer (2.5 to 4 years) and larger (about 2,000 patients in total), and tended to show some reduction in adenoma formation, by about 10%.

We now have results from two [1,2] large and relatively long trials ...

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