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NSAIDS, coxibs, aspirin, and GI bleeds.
Bandolier
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April 1, 2007
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COPYRIGHT 2007 Bandolier Ltd. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group.
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Guidance from various sources has suggested that any protective effect that coxibs have over non-selective NSAIDs is lost in the presence of low dose aspirin. This was based mainly on a meta-analysis of endoscopy studies with few events. A later meta-analysis showed that coxibs plus low dose aspirin produced fewer ulcers than NSAIDs plus low dose aspirin (Figure 1) [1]. What we have lacked is any evidence with real clinical outcomes. A new and very large observational study [2] fills the gap.
[FIGURE 1 OMITTED]
Study
This was a retrospective ...
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