Acquisition of apoptotic resistance in cadmium-transformed human prostate epithelial cells: Bcl-2 overexpression blocks the activation of JNK signal transduction pathway.(Research)(jun n-terminal kinases)

From: Environmental Health Perspectives | Date: July 1, 2007| Author: | Copyright information

BACKGROUND: We have recently shown that cadmium can induce malignant transformation of the human prostate epithelial cell line (RWPE-1) and that these cadmium-transformed prostate epithelial (CTPE) cells acquire apoptotic resistance concurrently with malignant phenotype.

OBJECTIVE: The present study was designed to define the mechanism of acquired apoptotic resistance in CTPE cells.

METHODS: Various molecular events associated with apoptosis were assessed in control and CTPE cells that were obtained after 8 weeks of continuous cadmium exposure.

RESULTS: Compared with ...

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