TGF-[beta] y un inhibidor especifico de TGF-[beta] regulan pericentrina B y MYH9 en celulas de glioma.

Revista Colombiana de Biotecnología | July 1, 2006| | Copyright

TGF-[beta] and a specific TGF-[beta] inhibitor regulate pericentrin B and MYH9 in glioma cell lines

ABSTRACT

Malignant gliomas are heterogeneous, highly invasive vascular tumours. The multifunctional cytokine, transforming growth factor-beta (TGF-[beta]), is expressed by grade III/FV gliomas and promotes tumour angiogenesis, invasion and immune escape. It has been shown previously that a small TGF-[beta] receptor type I (TGF-[beta]-RI) molecule inhibitor (SB-431542) blocks TGF-[beta]-mediated signal transduction, induction of angiogenic factor expression and cellular ...

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