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Virulence characteristics of Klebsiella and clinical manifestations of K. pneumoniae bloodstream infections.(RESEARCH)
From:
Emerging Infectious Diseases
| Date:
July 1, 2007| Author:
| COPYRIGHT 2007 U.S. National Center for Infectious Diseases. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group.Copyright information
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We studied 455 consecutive episodes of Klebsiella pneumoniae bacteremia occurring in 7 countries. Community-acquired pneumonia and an invasive syndrome of liver abscess, meningitis, or endophthalmitis occurred only in Taiwan and South Africa. Infections by K1 and K2 capsular serotype, the mucoid phenotype, and aerobactin production were important determinants of virulence. The mucoid phenotype was seen in 94% of isolates in patients with community-acquired pneumonia and in 100% of isolates that caused the invasive syndrome in Taiwan and South Africa, compared with only 2% of ...
<0.001). There was no association between human deaths and the presence of a mucoid strain (39% died) or a nonmucoid strain (35% died) (p>
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