Regulation of HTLV-1 Gag budding by Vps4A, Vps4B, and AIP1/Alix.(Research)(Human T-lymphotropic virus, vacuolar protein sorting 4 homolog A, vacuolar protein sorting 4 homolog B, A interacting protein 1)

The Gag polyprotein of HTLV-1 is the only viral protein that is both necessary for and sufficient to drive the release of virus particles through a budding process [1, 2, 3, 4, 5, 6, 7]. During or after the process of particle release, the action of the retroviral protease cleaves Gag to produce mature matrix (MA), capsid (CA), and nucleocapsid (NC) proteins. Three functional domains that are critical for the assembly and budding processes have been ...

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