The phosphorylation state of eNOS modulates vascular reactivity and outcome of cerebral ischemia in vivo.(Research article)(endothelial nitric oxide synthase)

Journal of Clinical Investigation | July 1, 2007| | Copyright

NO plays critical roles in vascular function. We show that modulation of the eNOS serine 1179 (S1179) phosphorylation site affects vascular reactivity and determines stroke size in vivo. Transgenic mice expressing only a phosphomimetic (S1179D) form of eNOS show greater vascular reactivity, develop less severe strokes, and have improved cerebral blood flow in a middle cerebral artery occlusion model than mice expressing an unphosphorylatable (S1179A) form. These results provide a molecular mechanism by which multiple diverse cardiovascular risks, such as diabetes and obesity, ...

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