Resistance to dihydroartemisinin.(Letter to the editor)

Emerging Infectious Diseases | May 1, 2007| | Copyright

To the Editor: The title of the letter by Cojean et al. (1) is misleading. The data presented essentially point to an absence of in vitro resistance to dihydroartemisinin (dhART) in the panel of African isolates studied, with 1 of 397 isolates having an elevated 50% inhibitory concentration ([IC.sub.50]) for dhART. The S769N PfATPase6 mutation associated with in vitro resistance to artemether (2) was observed in 1 isolate. This mutant isolate had a low [IC.sub.50] for dhART, but its [IC.sub.50] for artemether has not been tested. Since the relationship between in vitro ...

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