Comparison of ataxia-telangiectasia mutated protein expression in diffuse large B-cell lymphomas of primary central nervous system and non-central nervous system origin.(Clinical report)

From: Archives of Pathology & Laboratory Medicine | Date: March 1, 2007| Author: | Copyright information

* Context.--The ataxia-telangiectasia mutated (ATM) gene encodes a nuclear 370-kd phosphoprotein known to be associated with chromosomal regions containing doublestrand breaks. The mutations in the ATM gene may be involved in the development of some subtypes of sporadic lymphomas and leukemias. In primary central nervous system diffuse large B-cell lymphomas (PCNS DLBCLs), the pathogenetic role of ATM mutation has not been investigated.

Objective.--To investigate ATM protein expression in PCNS DLBCLs, in comparison with that in non-central nervous system (non-CNS) DLBCLs and ...

<20% of tumor cells; 2, 20% to approximately 50% of tumor cells; 3, 51% to approximately 80% of tumor cells; and 4,>
<60                 16 (38.1)      10 (23.8) 
  [greater than        5 (11.9)      11 (26.2)            .11 
  or equal to] 60 
 
Sex 
  M                   12 (28.6)      18 (42.9) 
  F                    9 (21.4)       3 (7.1)             .09 
 
Bcl-6 
  Negative            14 (33.3)       7 (16.7) 
  Positive             7 (16.7)      14 (33.3)            .06 
 
CD10 
  Negative            18 (42.9)      17 (40.5) 
  Positive             3 (7.1)        4 (9.5)>

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