Time-dependent patterning of the mesoderm and endoderm by Nodal signals in zebrafish.(Research article)

During vertebrate development, cells become irreversibly committed to particular fates after a series of inductive events. The first step of this process is completed during gastrulation, when cells are allocated to the three germ layers. Fate maps of vertebrate embryos show considerable organization before gastrulation, since different mesodermal and endodermal structures are derived from distinct positions along the major body axes [1, 2, 3]. In zebrafish late blastula ...

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