Induction of inflammation in vascular endothelial cells by metal oxide nanoparticles: effect of particle composition.(Research)(Clinical report)

From: Environmental Health Perspectives | Date: March 1, 2007| Author: Gojova, Andrea; Guo, Bing; Kota, Rama S.; Rutledge, John C.; Kennedy, Ian M.; Barakat Abdul I. | Copyright information

BACKGROUND: The mechanisms governing the correlation between exposure to ultrafine particles and the increased incidence of cardiovascular disease remain unknown. Ultrafine particles appear to cross the pulmonary epithelial barrier into the bloodstream, raising the possibility of direct contact with the vascular endothelium.

OBJECTIVES: Because endothelial inflammation is critical for the development of cardiovascular pathology, we hypothesized that direct exposure of hu...

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